Factors associated with acute coronary syndrome in patients hospitalized for COVID-19

Abstract

Objective: To evaluate the factors associated with acute coronary syndrome (ACS) in patients hospitalized for COVID-19 at the Hospital Nacional Edgardo Rebagliati Martins (Lima, Peru). Materials and methods: A case-control study was conducted, recruiting two groups of patients based on the diagnosis of ACS during their hospitalization for COVID-19 between March 2020 and March 2021 (60 cases and 120 controls). Sociodemographic and clinical factors and data related to the diagnosis and hospitalization for COVID-19 were measured. Associations and the
strength of association (odds ratio, OR) were assessed using nonparametric bivariate analyzes and logistic regression. Results: In the bivariate analysis, it was observed that a history of arterial hypertension, heart failure, coronary disease, cancer, and previous acute coronary syndrome were found to be associated with presenting SICA (systemic inflammatory response syndrome
in children and adolescents). Likewise, during hospitalization, it was observed that cough,
headache, systolic and diastolic blood pressure, sensory disorder, affected lobes, troponins, C-reactive protein, neutrophils, lymphocytes, and creatinine were associated with the event. In the multivariate analysis, only the aforementioned pathological antecedents were maintained. Conclusion: Although hospitalization for COVID-19 could be related to a higher frequency of SICA, the factors observed during hospitalization for COVID-19 would not significantly affect the occurrence of SICA.